There are 8 papers on MIR34C in aging research: 3 observational studies in people, 3 in animals, 2 in cells.
At a glance
The findings reach mice, none yet in people. 2 independent labs in 2 countries.
None of its findings points the other way.
- 2 independent labs in 2 countries
- Funders: National Heart, Lung, and Blood Institute and 3 more
- Humans3
- Animals3
- Cells2
Interventions
1Lead
upin mice1
1 study
Lead
upin mice1
Lead increases MIR34C in mice (adolescent exposure for three months).
“We also found miR-34c-3p expression was increased in the cortex of mice at the age of 16 months.”
Animalsadolescent exposure for three months0.2% lead acetate solutioncortex0.2%three monthsmales
Time-course miRNA alterations and SIRT1 inhibition triggered by adolescent lead exposure in mice
Toxicology research
Effects
1Senescence-associated beta-galactosidase
upin human cells1
1 study
Senescence-associated beta-galactosidase
upin human cells1
MIR34C increases senescence-associated beta-galactosidase in human cells (overexpression compared with control-treated cells) (38.2% versus 8.8%).
“Overexpression of miR-34a, miR-34b, or miR-34c in lung epithelial cells was associated with higher SA-βgal activity (27.8%, 35.1%, and 38.2%, respectively) relative to control treated cells (8.8%).”
Cellsoverexpression compared with control-treated cellslung epithelial cell
PloS one