There are 9 papers on MIR34B in aging research: 3 observational studies in people, 3 in animals, 2 in cells, 1 review.
At a glance
The findings reach cells, none yet in people. 4 independent labs in 2 countries.
None of its findings points the other way.
- 4 independent labs in 2 countries
- Funders: Department of Science and Technology, Hubei Provincial People's Government and 7 more
- Humans3
- Animals3
- Cells2
Interventions
1Low-frequency sinusoidal electromagnetic fields
downin rat cells1
1 study
Low-frequency sinusoidal electromagnetic fields
downin rat cells1
Low-frequency sinusoidal electromagnetic fields decrease MIR34B in rat cells.
“miR-34b-5p is downregulated in both the 0.4 mT and 1 mT SEMFs-stimulated groups.”
Cellslow-frequency sinusoidalbone marrow mesenchymal stem cell0.4 mT and 1 mT
Communications biology
Effects
7Osteogenic differentiation
downin rat cells1
1 study
Osteogenic differentiation
downin rat cells1
MIR34B inhibits osteogenic differentiation in rat cells (shown by mimic transfection and inhibition).
“miR-34b-5p mimic transfection suppress osteogenic differentiation, whereas inhibition of miR-34b-5p promote osteogenic differentiation of BMSCs.”
Cellsshown by mimic transfection and inhibitionbone marrow mesenchymal stem cell
Communications biology
Senescence-associated beta-galactosidase
upin human cells1
1 study
Senescence-associated beta-galactosidase
upin human cells1
MIR34B increases senescence-associated beta-galactosidase in human cells (overexpression compared with control-treated cells) (35.1% versus 8.8%).
“Overexpression of miR-34a, miR-34b, or miR-34c in lung epithelial cells was associated with higher SA-βgal activity (27.8%, 35.1%, and 38.2%, respectively) relative to control treated cells (8.8%).”
Cellsoverexpression compared with control-treated cellslung epithelial cell
PloS one
Endothelial tube formation
downin human cells1
1 study
Endothelial tube formation
downin human cells1
MIR34B inhibits endothelial tube formation in human cells (Shown by miR-34b-3p repression in senescent PDL44 HUVECs) (Repression increased total tube length approximately 1.7-fold (13 073/7 735) and branch points 2.3-fold (71/31)).
“Repression of miR-34b-3p had significantly increased proliferation, migration, total tube length and branch points”
CellsShown by miR-34b-3p repression in senescent PDL44 HUVECshuman umbilical vein endothelial cell
miR-34b-3p regulates the angiogenesis of senescent endothelial cell
Zhonghua yi xue za zhi
Endothelial cell migration
downin human cells1
1 study
Endothelial cell migration
downin human cells1
MIR34B inhibits endothelial cell migration in human cells (Shown by miR-34b-3p repression in senescent PDL44 HUVECs) (Repression increased migration approximately 2.3-fold (198/86)).
“Repression of miR-34b-3p had significantly increased proliferation, migration, total tube length and branch points”
CellsShown by miR-34b-3p repression in senescent PDL44 HUVECshuman umbilical vein endothelial cell
miR-34b-3p regulates the angiogenesis of senescent endothelial cell
Zhonghua yi xue za zhi
Endothelial cell proliferation
downin human cells1
1 study
Endothelial cell proliferation
downin human cells1
MIR34B inhibits endothelial cell proliferation in human cells (Shown by miR-34b-3p repression in senescent PDL44 HUVECs) (Repression increased proliferation approximately 1.4-fold (0.77/0.57)).
“Repression of miR-34b-3p had significantly increased proliferation, migration, total tube length and branch points”
CellsShown by miR-34b-3p repression in senescent PDL44 HUVECshuman umbilical vein endothelial cell
miR-34b-3p regulates the angiogenesis of senescent endothelial cell
Zhonghua yi xue za zhi
Col1a1 expression
downin human cells1
1 study
Col1a1 expression
downin human cells1
MIR34B decreases Col1a1 expression in human cells (transfection of miR-34b-5p mimics).
“transfection of miR-34b-5p mimics induced cell cycle arrest in HDFs, decreased the expression of both COL1A1 and elastin and increased MMP-1 expression.”
Cellstransfection of miR-34b-5p mimicsprimary human dermal fibroblast
The comparison of microRNA profile of the dermis between the young and elderly
Journal of dermatological science
Cell-cycle arrest
upin human cells1
1 study
Cell-cycle arrest
upin human cells1
MIR34B induces cell-cycle arrest in human cells (transfection of miR-34b-5p mimics).
“transfection of miR-34b-5p mimics induced cell cycle arrest in HDFs”
Cellstransfection of miR-34b-5p mimicsprimary human dermal fibroblast
The comparison of microRNA profile of the dermis between the young and elderly
Journal of dermatological science