MIR140

1 paper3 findings

HGNC NCBI Gene Taxon

1 lab in 1 country

Funders: Aix-Marseille Université and 2 more

Cells1

Effects

3

Oxidative phosphorylation

downin human cells1

1 study

MIR140 decreases oxidative phosphorylation in human cells.
“miR-140-5p overexpression induces mitochondrial dysfunction, characterized by a reduced oxidative phosphorylation capacity”
Cellsin HGPS fibroblasts
miR-140-5p Overexpression Contributes to Oxidative Stress and Mitochondrial Dysfunction in Hutchinson-Gilford Progeria Syndrome Fibroblasts Through NRF2 Pathway
Aging cell31 Oct 2025

More on Oxidative phosphorylation

Oxidative stress

upin human cells1

1 study

MIR140 increases oxidative stress in human cells.
“miR-140-5p overexpression in HGPS fibroblasts results in the downregulation of the NRF2/KEAP1/HO-1 antioxidant pathway, leading to increased oxidative stress”
Cellsin HGPS fibroblasts
miR-140-5p Overexpression Contributes to Oxidative Stress and Mitochondrial Dysfunction in Hutchinson-Gilford Progeria Syndrome Fibroblasts Through NRF2 Pathway
Aging cell31 Oct 2025

NRF2–KEAP1 antioxidant response

downin human cells1

1 study

MIR140 inhibits NRF2–KEAP1 antioxidant response in human cells.
“miR-140-5p overexpression in HGPS fibroblasts results in the downregulation of the NRF2/KEAP1/HO-1 antioxidant pathway”
Cellsin HGPS fibroblasts
miR-140-5p Overexpression Contributes to Oxidative Stress and Mitochondrial Dysfunction in Hutchinson-Gilford Progeria Syndrome Fibroblasts Through NRF2 Pathway
Aging cell31 Oct 2025

More on NRF2–KEAP1 antioxidant response

Latest

Aging Cell31 Oct

miR-140-5p Overexpression Contributes to Oxidative Stress and Mitochondrial Dysfunction in Hutchinson-Gilford Progeria Syndrome Fibroblasts Through NRF2 Pathway

Experiments in human cellsNRF2–KEAP1 antioxidant response