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MAPK12

Gene

3 papers2 findings

HGNCNCBI GeneTaxon

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Includes the processes named after it and trials of drugs aimed at it.

  • 1 lab in 1 country
  • Animals2
  • Cells1

Effects

2

Joint pain

downin mice1

1 study

  1. MAPK12 decreases joint pain in mice.

    “both MAPK12 over-expression and FOS knock-down can promote cell proliferation and cartilage anabolism, inhibit cell senescence and cartilage catabolism, relieve joint pain”

    Animalsin DMM mice

    Targeting the senescence-related genes MAPK12 and FOS to alleviate osteoarthritis

    Journal of orthopaedic translationJun 20, 2024

Cellular senescence

downin mice1

1 study

  1. MAPK12 inhibits cellular senescence in mice.

    “both MAPK12 over-expression and FOS knock-down can promote cell proliferation and cartilage anabolism, inhibit cell senescence and cartilage catabolism, relieve joint pain”

    Animalsin DMM mice and H2O2- or IL-1β-stimulated chondrocytes

    Targeting the senescence-related genes MAPK12 and FOS to alleviate osteoarthritis

    Journal of orthopaedic translationJun 20, 2024

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