mafr-1

1. mafr-1 increases paralysis in worms.

   “mafr-1 deletion also attenuates the paralysis of a C. elegans model of Alzheimer's disease.”

   Model organismsAlzheimer's disease model; shown by mafr-1 deletion

   Stress resistance and lifespan are increased in C. elegans but decreased in S. cerevisiae by mafr-1/maf1 deletion

   Oncotarget·Mar 5, 2016

1. mafr-1 inhibits autophagy in worms.

   “mafr-1 deletion on lifespan is due to an enhancement of stress response, including oxidative stress response, mitochondrial unfolded protein response (UPRmt) and autophagy.”

   Model organismsshown by mafr-1 deletion

   Stress resistance and lifespan are increased in C. elegans but decreased in S. cerevisiae by mafr-1/maf1 deletion

   Oncotarget·Mar 5, 2016

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