Maf1
- 1 lab in 1 country
- Funders: Biotechnology and Biological Sciences Research Council and 4 more
- Model organisms1
Effects
5protein synthesis
downin flies1
1 study
protein synthesis
downin flies1
Maf1 decreases protein synthesis in flies.
“Indeed, reducing neuronal Maf1 activity rescues the age-related decline in 5S expression and protein synthesis in the brain of female flies.”
Model organismsage-related decline, shown by reducing neuronal Maf1 activitybrainfemales
PLoS biology15 Jul 2025
5S rRNA expression
downin flies1
1 study
5S rRNA expression
downin flies1
Maf1 decreases 5S rRNA expression in flies.
“Indeed, reducing neuronal Maf1 activity rescues the age-related decline in 5S expression and protein synthesis in the brain of female flies.”
Model organismsage-related decline, shown by reducing neuronal Maf1 activitybrainfemales
PLoS biology15 Jul 2025
Gut function
downin flies1
1 study
Gut function
downin flies1
Maf1 impairs gut function in flies.
“In older females, adult neuron-specific knockdown of Maf1 improves neuromuscular function as well as the function of a distal organ, the gut.”
Model organismsshown by adult neuron-specific Maf1 knockdowngutfemales
PLoS biology15 Jul 2025
Neuromuscular function
downin flies1
1 study
Neuromuscular function
downin flies1
Maf1 impairs neuromuscular function in flies.
“In older females, adult neuron-specific knockdown of Maf1 improves neuromuscular function as well as the function of a distal organ, the gut.”
Model organismsshown by adult neuron-specific Maf1 knockdownneuronfemales
PLoS biology15 Jul 2025
Lifespan
downin flies1
1 study
Lifespan
downin flies1
Maf1 shortens lifespan in flies.
“Maf1 limits longevity specifically from adult neurons in both female and male fruit flies.”
Model organismsshown by Maf1 knockdownneuron
PLoS biology15 Jul 2025