lin-24

1. lin-24 induces mitochondrial fission and fusion in worms.

   “Furthermore, we demonstrate that LIN-24 induces the formation of donut-shaped mitochondria”

   Model organismsduring starvation

   Pore-Forming Protein LIN-24 Enhances Starvation Resilience in Caenorhabditis elegans by Modulating Lipid Metabolism and Mitochondrial Dynamics

   Toxins·Feb 6, 2025

More on Mitochondrial fission and fusion

1. lin-24 improves muscle structure in worms.

   “LIN-24 overexpression significantly preserves muscle integrity, as evidenced by the maintenance of muscle structure compared to wild-type worms.”

   Model organismsLIN-24 overexpression during starvation

   Pore-Forming Protein LIN-24 Enhances Starvation Resilience in Caenorhabditis elegans by Modulating Lipid Metabolism and Mitochondrial Dynamics

   Toxins·Feb 6, 2025

1. lin-24 increases lipl-3 in worms.

   “leading to increased expression of the lipase-encoding gene lipl-3.”

   Model organismsduring starvation

   Pore-Forming Protein LIN-24 Enhances Starvation Resilience in Caenorhabditis elegans by Modulating Lipid Metabolism and Mitochondrial Dynamics

   Toxins·Feb 6, 2025

More on lipl-3

1. lin-24 improves starvation resistance in worms.

   “uncover its novel function in enhancing starvation resistance.”

   Model organismsduring starvation

   Pore-Forming Protein LIN-24 Enhances Starvation Resilience in Caenorhabditis elegans by Modulating Lipid Metabolism and Mitochondrial Dynamics

   Toxins·Feb 6, 2025

1. lin-24 decreases bacterial load in worms.

   “worms showing longer survival time and reduced bacterial load.”

   Model organismsLIN-24 overexpression during PA14 infection

   Caenorhabditis elegans LIN-24, a homolog of bacterial pore-forming toxin, protects the host from microbial infection

   FASEB journal : official publication of the Federation of American Societies for Experimental Biology·Sep 8, 2023

1. lin-24 decreases lifespan in worms.

   “LIN-24 knockdown reduced the maximum lifespan of worms.”

   Model organismsknockdown

   Caenorhabditis elegans LIN-24, a homolog of bacterial pore-forming toxin, protects the host from microbial infection

   FASEB journal : official publication of the Federation of American Societies for Experimental Biology·Sep 8, 2023