lin-15B

1 paper2 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

A gene’s or a process’s line counts the gene with the processes named after it, as NLRP3 with the NLRP3 inflammasome, and the trials of drugs aimed at it.

1 lab in 1 country

Model organisms1

Effects

DNA repair gene expression

upin worms1

1 study

lin-15B increases DNA repair gene expression in worms.
“Nuclear LIN-15B then activates a broad transcriptional program encompassing core UPRmt targets and a unique set of DNA repair genes.”
Model organismsFollowing nuclear translocation of LIN-15B
A Surveillance Pathway Senses Leaked Mitochondrial DNA to Activate UPRmt and Promote Longevity
Preprint13 Jan 2026Preprint

Latest

1 in 12 months

Preprint13 Jan

A Surveillance Pathway Senses Leaked Mitochondrial DNA to Activate UPRmt and Promote Longevity

Preprint: experiments in wormsMitochondrion

Paper

lin-15B

Effects

Latest

A Surveillance Pathway Senses Leaked Mitochondrial DNA to Activate UPRmt and Promote Longevity

Related