LGALS3BP

Gene

4 papers2 findings

  • 2 independent labs in 1 country
  • Funder: Natural Science Foundation of Henan Province
  • Humans2
  • Animals2

Effects

2

Ovarian function

is required forin mice1

1 study
  1. LGALS3BP is required for ovarian function in mice.

    “absence of LGALS3BP in UCMSC-EVs impaired the amelioration of inflammatory and the functional improvement in ovarian senescence”

    Animalsin UCMSC-EVs

    Mesenchymal stem cells derived extracellular vesicles ameliorate ovarian aging through inhibiting LGALS3BP/NF-κB induced inflammation

    Journal of ovarian research22 Dec 2025

Inflammation

upin mouse cells1

1 study
  1. LGALS3BP increases inflammation in mouse cells.

    “upregulation of Lgals3bp in aortic fibroblasts of HGPS mice, which promoted the expression of pro-inflammatory factors and fibrosis-related genes.”

    Cellsin HGPS cells

    Single-cell RNA sequencing analysis reveals the critical role of fibroblasts in aortic progeria-associated vascular remodeling in Hutchinson-Gilford progeria syndrome mice

    Frontiers in immunology24 Oct 2025

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