LANCL1

1. LANCL1 decreases pro-inflammatory cytokines in mice.

   “detected elevated expression of pro inflammatory cytokines in regenerating LTKO muscles”

   Animalsshown by triple knockout after barium chloride injuryskeletal muscle

   Loss of LanC-like proteins delays post-injury regeneration of aging skeletal muscles

   bioRxiv : the preprint server for biology·15 Jun 2026Preprint

More on Pro-inflammatory cytokines

1. LANCL1 improves muscle regeneration in mice.

   “delayed regeneration of the tibialis anterior (TA) muscle after injury, as reflected by reduced sizes of regenerating myofibers at day 7 after injury in middle-aged (but not young) LTKO compared to age-matched WT mice”

   Animalsshown by triple knockout after barium chloride injurytibialis anterior muscle

   Loss of LanC-like proteins delays post-injury regeneration of aging skeletal muscles

   bioRxiv : the preprint server for biology·15 Jun 2026Preprint

1. LANCL1 activates PI3K–AKT signalling in mice.

   “LanCL1 is a positive regulator of AKT activity, and LanCL1 overexpression restores the impaired AKT activity in ALS model mice.”

   Animalsin SOD1G93A mice

   LanCL1 promotes motor neuron survival and extends the lifespan of amyotrophic lateral sclerosis mice

   Cell death and differentiation·30 Sep 2019

More on PI3K–AKT signalling

1. LANCL1 prevents motor neuron loss in mice.

   “Conversely, CNS-specific deletion of LanCL1 leads to neurodegenerative phenotypes, including motor neuron loss, neuroinflammation, and oxidative damage.”

   AnimalsCNS-specific deletioncentral nervous system

   LanCL1 promotes motor neuron survival and extends the lifespan of amyotrophic lateral sclerosis mice

   Cell death and differentiation·30 Sep 2019

1. LANCL1 improves motor performance in mice.

   “CNS-specific expression of LanCL1 transgene extends lifespan, delays disease onset, decelerates symptomatic progression, and improves motor performance of SOD1G93A mice.”

   Animalsin SOD1G93A micecentral nervous system

   LanCL1 promotes motor neuron survival and extends the lifespan of amyotrophic lateral sclerosis mice

   Cell death and differentiation·30 Sep 2019

1. LANCL1 extends lifespan in mice.

   “CNS-specific expression of LanCL1 transgene extends lifespan, delays disease onset, decelerates symptomatic progression, and improves motor performance of SOD1G93A mice.”

   Animalsin SOD1G93A micecentral nervous system

   LanCL1 promotes motor neuron survival and extends the lifespan of amyotrophic lateral sclerosis mice

   Cell death and differentiation·30 Sep 2019