JPX

1. Dasatinib + quercetin decreases JPX in human cells.

   “Senolytics alleviated endothelial senescence while suppressing the upregulation of JPX observed in senescent HUVECs.”

   Cellsin LPS-treated HUVECs

   The anti-aging drug Senolytics alleviates vascular endothelial cell senescence by antagonizing the JPX-BRD4-p65 complex

   Cellular signalling·23 Dec 2025

More on Dasatinib + quercetin

1. JPX increases senescence-associated secretory phenotype (SASP) in human cells.

   “JPX interacted with bromodomain-containing protein 4 (BRD4) and transcription factor p65 to form a JPX-BRD4-p65 complex that promoted SASP expression.”

   Cellsvia JPX-BRD4-p65 complex in endothelial cells

   The anti-aging drug Senolytics alleviates vascular endothelial cell senescence by antagonizing the JPX-BRD4-p65 complex

   Cellular signalling·23 Dec 2025

More on Senescence-associated secretory phenotype (SASP)

1. JPX increases endothelial cell senescence in human cells.

   “JPX knockdown inhibited, whereas JPX overexpression aggravated, EC senescence.”

   Cellsfunctional assays in HUVECs

   The anti-aging drug Senolytics alleviates vascular endothelial cell senescence by antagonizing the JPX-BRD4-p65 complex

   Cellular signalling·23 Dec 2025