jouvence

jouvence extends lifespan in flies.

“re-expression of each snoRNA in the enterocytes or in the fat body is sufficient to improve lifespan and protect against neurodegeneration in old flies”

Model organismsin the context of the F4 deletion

A Cluster of Three snoRNAs Including Jouvence Required in the Gut Determines Lifespan and Confers Neuroprotection Through Metabolic Parameters

Aging cell·Mar 31, 2026

jouvence extends lifespan in flies.

“while its overexpression in wild-type increases lifespan”

Model organismsgut

Jouvence a small nucleolar RNA required in the gut extends lifespan in Drosophila

Nature communications·Feb 20, 2020

jouvence extends lifespan in flies.

“Targeted expression of jouvence specifically in the enterocytes increases lifespan”

Model organismstargeted expression in enterocytesenterocyte

jouvence , a new small nucleolar RNA required in the gut extends lifespan in Drosophila

bioRxiv (Cold Spring Harbor Laboratory)·Oct 11, 2018Preprint

jouvence protects against neurodegenerative lesions in flies.

“re-expression of each snoRNA in the enterocytes or in the fat body is sufficient to improve lifespan and protect against neurodegeneration in old flies”

Model organismsin the context of the F4 deletion

A Cluster of Three snoRNAs Including Jouvence Required in the Gut Determines Lifespan and Confers Neuroprotection Through Metabolic Parameters

Aging cell·Mar 31, 2026

jouvence prevents intestinal hyperplasia in flies.

“the overexpression of jouvence prevents it”

Model organismsoverexpressiongut

Jouvence a small nucleolar RNA required in the gut extends lifespan in Drosophila

Nature communications·Feb 20, 2020