ITIH5

1. ITIH5 protects against corneal clouding in mice.

   “Itih5-/- mice presented early-onset geriatric decline including corneal clouding, loss of corneal smoothness and corneal epithelial defects”

   Animalscornea

   A loss of inter-α-inhibitor Heavy Chain 5 (ITIH5) leads to corneal thinning and increased corneal inflammation following injury and early onset geriatric decline

   The ocular surface·24 Feb 2026

1. ITIH5 increases corneal thickness in mice.

   “Itih5-/- mice presented thinner corneas than age matched WT mice.”

   Animalscornea

   A loss of inter-α-inhibitor Heavy Chain 5 (ITIH5) leads to corneal thinning and increased corneal inflammation following injury and early onset geriatric decline

   The ocular surface·24 Feb 2026

1. ITIH5 decreases corneal scarring in mice.

   “increased scar tissue deposition, angiogenesis and epithelial erosions present at 2 weeks and 1 month after injury.”

   Animalsafter alkali burn injurycornea

   A loss of inter-α-inhibitor Heavy Chain 5 (ITIH5) leads to corneal thinning and increased corneal inflammation following injury and early onset geriatric decline

   The ocular surface·24 Feb 2026

1. ITIH5 decreases inflammation in mice.

   “Upon injury, Itih5-/- mice presented increased and sustained inflammation”

   Animalsafter alkali burn injurycornea

   A loss of inter-α-inhibitor Heavy Chain 5 (ITIH5) leads to corneal thinning and increased corneal inflammation following injury and early onset geriatric decline

   The ocular surface·24 Feb 2026

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