IRAK3

1. IRAK3 decreases osteoarthritis in mice.

   “intra-articular injection of adeno-associated virus (AAV) to knock down IRAK3 can promote the progression of OA in DMM mice.”

   Animalsin DMM micecartilage

   Interleukin-1 Receptor-Associated Kinase 3 Attenuates Chondrocyte Senescence and Osteoarthritis via Inhibition of the TLR7/9-NF-κB Axis

   Journal of molecular histology·Apr 24, 2026

More on Osteoarthritis

1. IRAK3 decreases chondrocyte senescence in mouse cells.

   “IRAK3 inhibited the TLR7/TLR9–NF-κB pathway, leading to decreased secretion of pro-inflammatory cytokines and reduced chondrocyte senescence.”

   Cellsin ATDC5 chondrocytescartilage

   Interleukin-1 Receptor-Associated Kinase 3 Attenuates Chondrocyte Senescence and Osteoarthritis via Inhibition of the TLR7/9-NF-κB Axis

   Journal of molecular histology·Apr 24, 2026

1. IRAK3 inhibits cellular senescence in mice.

   “The absence of IRAK-M led to a disruption in RPE cell homeostasis, characterized by compromised mitochondrial function, cellular senescence, and aberrant cytokine production.”

   Animalsshown by knockout

   Replenishing IRAK-M expression in retinal pigment epithelium attenuates outer retinal degeneration

   Science translational medicine·Jun 5, 2024

More on Cellular senescence

1. IRAK3 protects against outer retinal degeneration in mice.

   “Irak3-knockout mice exhibited an increased incidence of outer retinal degeneration at earlier ages”

   Animalsshown by knockout

   Replenishing IRAK-M expression in retinal pigment epithelium attenuates outer retinal degeneration

   Science translational medicine·Jun 5, 2024

More on Outer retinal degeneration

1. IRAK3 protects against cellular homeostasis in mouse cells.

   “IRAK-M overexpression protected RPE cells against oxidative or immune stressors.”

   Cellsoxidative or immune stressors

   Replenishing Age-Related Decline of IRAK-M Expression in Retinal Pigment Epithelium Attenuates Outer Retinal Degeneration

   bioRxiv : the preprint server for biology·Sep 29, 2023Preprint

More on Cellular homeostasis

1. IRAK3 is associated with age-related macular degeneration in humans.

   “Rare genetic variants of IRAK3, which encodes IRAK-M, were associated with an increased likelihood of developing AMD.”

   Humansrare genetic variants

   Replenishing IRAK-M expression in retinal pigment epithelium attenuates outer retinal degeneration

   Science translational medicine·Jun 5, 2024

2. IRAK3 raises the risk of age-related macular degeneration in humans.

   “Rare genetic variants of IRAK-M increased the likelihood of AMD.”

   Humansrare genetic variants

   Replenishing Age-Related Decline of IRAK-M Expression in Retinal Pigment Epithelium Attenuates Outer Retinal Degeneration

   bioRxiv : the preprint server for biology·Sep 29, 2023Preprint

More on Age-related macular degeneration

1. IRAK3 raises the risk of outer retinal degeneration in mice.

   “IRAK-M-deficient mice exhibited increased incidence of outer retinal degeneration at earlier ages”

   AnimalsIRAK-M deficiency

   Replenishing Age-Related Decline of IRAK-M Expression in Retinal Pigment Epithelium Attenuates Outer Retinal Degeneration

   bioRxiv : the preprint server for biology·Sep 29, 2023Preprint

More on Outer retinal degeneration