Outer retinal degeneration
2 papers4 findings
- Humans1
- Animals1
Interventions
2AAV-IRAK3
downin mice1
1 study
AAV-IRAK3
downin mice1
AAV-IRAK3 protects against outer retinal degeneration in mice.
“Subretinal delivery of adeno-associated virus (AAV)-expressing human IRAK3 rescued light-induced outer retinal degeneration in wild-type mice”
Animalslight-induced outer retinal degeneration
Replenishing IRAK-M expression in retinal pigment epithelium attenuates outer retinal degeneration
Science translational medicineJun 5, 2024
Aav-irak-m
downin mice1
1 study
Aav-irak-m
downin mice1
Aav-irak-m decreases outer retinal degeneration in mice.
“Subretinal delivery of AAV-expressing IRAK-M rescued light-induced outer retinal degeneration in wild-type mice”
Animalslight-induced
bioRxiv : the preprint server for biologySep 29, 2023Preprint
Upstream
1IRAK3
downin mice1
1 study
IRAK3
downin mice1
IRAK3 protects against outer retinal degeneration in mice.
“Irak3-knockout mice exhibited an increased incidence of outer retinal degeneration at earlier ages”
Animalsshown by knockout
Replenishing IRAK-M expression in retinal pigment epithelium attenuates outer retinal degeneration
Science translational medicineJun 5, 2024
Associations
1IRAK3
upin mice1
1 study
IRAK3
upin mice1
IRAK3 raises the risk of outer retinal degeneration in mice.
“IRAK-M-deficient mice exhibited increased incidence of outer retinal degeneration at earlier ages”
AnimalsIRAK-M deficiency
bioRxiv : the preprint server for biologySep 29, 2023Preprint