ILK

1. ILK protects against cellular senescence in human cells.

   “ILK depletion in young ECs was sufficient to trigger a senescence-associated phenotype”

   Cellsdepletion in young endothelial cells

   Integrin-Linked Kinase Plays an Active Role in the Regulation of Endothelial Senescence

   Cells·14 Jun 2026

More on Cellular senescence

1. ILK increases myocardial injury in rats.

   “ILK overexpression blunted the benefits of exercise, with the model + treadmill + OE-ILK group showing the most severe injury.”

   Animalsshown by overexpression

   Rehabilitation exercise improves aging myocardial injury by suppressing the ILK/integrin β3αv/p38 MAPK signaling pathway

   Biochemical and biophysical research communications·5 May 2026

More on Myocardial injury

1. ILK decreases maturation of nephrogenic cells in mice.

   “Maturation of nephrogenic cells in IlkT173I-knock-in kidneys was decreased”

   AnimalsIlkT173I knock-inkidney

   Increased mTOR signaling secondary to a human ILK missense variant inhibits nephrogenesis with decreased metabolism

   Mechanisms of ageing and development·19 Sep 2025

1. ILK decreases ureteric branching in mice.

   “Replacement of the mouse ILKWT allele with IlkT173I caused increased kidney mTOR signaling, low nephron number, and decreased ureteric branching”

   AnimalsIlkT173I knock-inkidney

   Increased mTOR signaling secondary to a human ILK missense variant inhibits nephrogenesis with decreased metabolism

   Mechanisms of ageing and development·19 Sep 2025