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HTRA3

Gene

1 paper2 findings

HGNCNCBI GeneTaxon

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

Includes the processes named after it and trials of drugs aimed at it.

  • 1 lab in 1 country
  • Funders: Agence Nationale de la Recherche and 3 more
  • 2 of 2 findings with company ties
  • Cells1

Effects

2

RAC1 protein stability

upin human cells1

1 study

  1. HTRA3 increases RAC1 protein stability in human cells.

    “This degradation is in part counteracted by RAC1, a small GTPase also stabilized by HTRA3.”

    Cells

    HTRA3 protease-chaperone stabilizes cathepsin B for mitochondrial POLG1 depletion in human cell ageing

    bioRxiv (Cold Spring Harbor Laboratory)Jul 21, 2025Preprint

CTSB protein stability

upin human cells1

1 study

  1. HTRA3 increases CTSB protein stability in human cells.

    “cathepsin B, which is overexpressed, escapes from lysosomes, and is stabilized by the chaperone activity of another protease, HTRA3.”

    Cellsnormal and accelerated ageing cells

    HTRA3 protease-chaperone stabilizes cathepsin B for mitochondrial POLG1 depletion in human cell ageing

    bioRxiv (Cold Spring Harbor Laboratory)Jul 21, 2025Preprint

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