POLG protein abundance

1. CTSB decreases POLG protein abundance in human cells.

   “POLG1, the enzyme responsible for mitochondrial DNA replication, is degraded by the protease cathepsin B”

   Cellsnormal and accelerated ageing cells

   HTRA3 protease-chaperone stabilizes cathepsin B for mitochondrial POLG1 depletion in human cell ageing

   bioRxiv (Cold Spring Harbor Laboratory)·Jul 21, 2025Preprint

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