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hpo

Gene

1 paper2 findings

NCBI GeneTaxon

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Against: findings that point the other way from most findings on the same outcome.

Includes the processes named after it and trials of drugs aimed at it.

  • 1 lab in 1 country
  • 1 finding against
  • Funders: Department of Veterans' Affairs, Australian Government and others
  • Model organisms1

Effects

1

Lifespan

upin flies1downin flies1

1 study

  1. hpo extends lifespan in flies.

    “RNAi Hpo depletion increased lifespan”

    Model organismsRNAi depletion

    Phosphorylation of an RNA-Binding Protein Rck/Me31b by Hippo Is Essential for Adipose Tissue Aging

    Aging cell11 Mar 2025

  2. hpo shortens lifespan in flies.

    “overexpression of Hpo, the MST1 homolog in Drosophila melanogaster, decreased lifespan”

    Model organismsoverexpression

    Phosphorylation of an RNA-Binding Protein Rck/Me31b by Hippo Is Essential for Adipose Tissue Aging

    Aging cell11 Mar 2025

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