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HPF1

Gene

2 papers study it4 findings

Taxon

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Includes the processes named after it and trials of drugs aimed at it.

  • 2 independent labs in 1 country
  • Cells2

Effects

4

Stem cell differentiation

downin rats1

1 study

  1. HPF1 decreases stem cell differentiation in rats.

    “HPF1 or PARP1 overexpression could both inhibit the ability of tendon differentiation and promote cell senescence.”

    Animalsoverexpressiontendon

    HPF1 regulates tendon stem/progenitor cell senescence and tendon repair via PARP1-mediated poly-ADP ribosylation of HuR

    Genes & genomicsSep 15, 2023

More on Stem cell differentiation

Cellular senescence

upin rats1

1 study

  1. HPF1 increases cellular senescence in rats.

    “in vivo experiments have shown that HPF1 or PARP1 overexpression could both inhibit the ability of tendon differentiation and promote cell senescence.”

    Animalsoverexpressiontendon

    HPF1 regulates tendon stem/progenitor cell senescence and tendon repair via PARP1-mediated poly-ADP ribosylation of HuR

    Genes & genomicsSep 15, 2023

More on Cellular senescence

Cell buoyancy

upin yeast cells1

1 study

  1. HPF1 increases cell buoyancy in yeast cells.

    “The HPF1 repeat expansion shifted yeast cells from a sedentary to a buoyant state, thereby increasing their exposure to surrounding oxygen.”

    Cellsrepeat expansion

    Intragenic repeat expansions control yeast chronological aging

    bioRxiv (Cold Spring Harbor Laboratory)May 30, 2019Preprint

Lifespan

downin yeast cells1

1 study

  1. HPF1 shortens lifespan in yeast cells.

    “massive expansions of intragenic tandem repeats in the cell wall glycoproteins FLO11 and HPF1 , which caused a dramatic life span shortening.”

    Cellsintragenic tandem repeat expansion

    Intragenic repeat expansions control yeast chronological aging

    bioRxiv (Cold Spring Harbor Laboratory)May 30, 2019Preprint

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