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HOG1

There are 7 papers on HOG1 in aging research: none in people yet, 7 in cells.

Gene

7 papers study it5 findings

Taxon

See all 7 papers on HOG1

At a glance

The findings reach worms or flies, none yet in people. 3 independent labs in 3 countries.

None of its findings points the other way.

Worms or flies: a single group. Cells, mice and humans: nothing yet.

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Includes the processes named after it and trials of drugs aimed at it.

  • 3 independent labs in 3 countries
  • Funders: Agence Nationale de la Recherche and 8 more
  • Cells7

Effects

4

Reactive oxygen species

downin yeast cells2

2 studies

  1. HOG1 decreases reactive oxygen species in yeast cells During replicative senescence in telomerase-negative cells; examined using HOG1 deletion.

    “Hog1 counteracts increased ROS levels during replicative senescence.”

    CellsDuring replicative senescence in telomerase-negative cells; examined using HOG1 deletion

    Hog1 acts in a Mec1-independent manner to counteract oxidative stress following telomerase inactivation in Saccharomyces cerevisiae

    Communications biology

  2. HOG1 decreases reactive oxygen species in yeast cells (Hog1 activation dependent on Pbs2; during replicative senescence).

    “counteracts increased ROS levels during replicative senescence”

    CellsHog1 activation dependent on Pbs2; during replicative senescence

    Hog1 acts in a Mec1-independent manner to counteract oxidative stress following telomerase inactivation

    bioRxiv (Cold Spring Harbor Laboratory)Preprint

More on Reactive oxygen species

Cellular senescence

downin yeast cells1

1 study

  1. HOG1 protects against cellular senescence in yeast cells (shown by deletion).

    “While Hog1 deletion accelerates replicative senescence”

    Cellsshown by deletion

    Hog1 acts in a Mec1-independent manner to counteract oxidative stress following telomerase inactivation

    bioRxiv (Cold Spring Harbor Laboratory)Preprint

More on Cellular senescence

Nuclear translocation of Msn2

upin yeast cells1

1 study

  1. HOG1 activates nuclear translocation of Msn2 in smi1Δ cells.

    “the activation of Hog1 induces the translocation of Msn2 into the nucleus”

    Cellsin smi1Δ cells

    Loss of Smi1, a protein involved in cell wall synthesis, extends replicative life span by enhancing rDNA stability in Saccharomyces cerevisiae

    The Journal of biological chemistry

Chronological lifespan

downin yeast cells1

1 study

  1. HOG1 shortens chronological lifespan in yeast cells (shown by HOG1 deletion).

    “Using both qualitative and quantitative CLS assays, we show that deletion of any of the three MAPK's increases yeast lifespan.”

    Cellsshown by HOG1 deletion

    Mitogen-activated protein kinases, Fus3 and Kss1, regulate chronological lifespan in yeast

    Aging

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