MEC1

1. MEC1 induces cellular senescence in yeast.

   “Tel1/ATM and Mec1/ATR contribute to telomere length maintenance and arrest cell cycle progression when chromosome ends shorten, thus promoting a tumor-suppressive process known as replicative senescence.”

   Reviewwhen chromosome ends shorten

   The regulation of the DNA damage response at telomeres: focus on kinases

   Biochemical Society transactions·30 Apr 2021

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