HNRNPK

1. HNRNPK induces cellular senescence in mice.

   “HNRNPK overexpression caused alterations in the nucleolar structure, resulting in p53-dependent nucleolar stress, cell cycle arrest, senescence, and bone marrow failure phenotype”

   AnimalsHNRNPK overexpression

   The tumor suppressor HNRNPK induces p53-dependent nucleolar stress to drive ribosomopathies

   The Journal of clinical investigation·8 May 2025

2. HNRNPK induces cellular senescence in cells.

   “Hnrnpk overexpression and nucleolar stress trigger cell cycle arrest and senescence of the cells”

   CellsHnrnpk overexpression

   The nucleolar aberrancies that drive ribosome impairment induced by RNA binding proteins are hallmarks of aging

   bioRxiv (Cold Spring Harbor Laboratory)·7 Mar 2023Preprint

More on Cellular senescence

1. HNRNPK impairs translation in mice.

   “These models showed disruptions in translation as the HNRNPK overexpression caused alterations in the nucleolar structure”

   AnimalsHNRNPK overexpression

   The tumor suppressor HNRNPK induces p53-dependent nucleolar stress to drive ribosomopathies

   The Journal of clinical investigation·8 May 2025

1. HNRNPK induces bone marrow failure in mice.

   “resulting in p53-dependent nucleolar stress, cell cycle arrest, senescence, and bone marrow failure phenotype”

   AnimalsHNRNPK overexpression

   The tumor suppressor HNRNPK induces p53-dependent nucleolar stress to drive ribosomopathies

   The Journal of clinical investigation·8 May 2025

More on Bone marrow failure

1. HNRNPK induces cell-cycle arrest in cells.

   “Hnrnpk overexpression and nucleolar stress trigger cell cycle arrest and senescence of the cells”

   CellsHnrnpk overexpression

   The nucleolar aberrancies that drive ribosome impairment induced by RNA binding proteins are hallmarks of aging

   bioRxiv (Cold Spring Harbor Laboratory)·7 Mar 2023Preprint

1. HNRNPK inhibits protein translation in cells.

   “with accumulation and delocalization of components such as Ncl, driving ribosome biogenesis impairment and halting protein translation.”

   CellsHnrnpk overexpression

   The nucleolar aberrancies that drive ribosome impairment induced by RNA binding proteins are hallmarks of aging

   bioRxiv (Cold Spring Harbor Laboratory)·7 Mar 2023Preprint

1. HNRNPK impairs ribosome biogenesis in cells.

   “with accumulation and delocalization of components such as Ncl, driving ribosome biogenesis impairment and halting protein translation.”

   CellsHnrnpk overexpression

   The nucleolar aberrancies that drive ribosome impairment induced by RNA binding proteins are hallmarks of aging

   bioRxiv (Cold Spring Harbor Laboratory)·7 Mar 2023Preprint

1. HNRNPK is associated with hnRNP K mislocalisation in humans.

   “hnRNP K mislocalisation is observed throughout the brain, characterised by nuclear depletion and cytoplasmic aggregation.”

   HumansFTLD, PD, AD and age-matched controlsbrain

   Widespread hnRNP K Mislocalisation Suggests Differential Neuronal Vulnerability in the Neurodegenerative and Ageing Human Brain

   Neuropathology and applied neurobiology·1 Apr 2026

More on hnRNP K mislocalisation

1. HNRNPK is associated with motor symptoms in humans.

   “levels of hnRNP K mislocalisation within the putamen correlated significantly with motor symptoms”

   Humansputamen

   Widespread hnRNP K Mislocalisation Suggests Differential Neuronal Vulnerability in the Neurodegenerative and Ageing Human Brain

   Neuropathology and applied neurobiology·1 Apr 2026