HIVEP3

1. HIVEP3 is associated with cognitive SuperAging in humans (OR = 0.61, p = 0.032).

   “These variants were nominally associated when comparing SA to CU 80+ (rs12734651, OR = 0.61, p = 0.032).”

   Humanscomparing SA to CU 80+

   Common genetic variants in HIVEP3 are associated with cognitive SuperAging in the Amish

   AAIC 2025 abstract·24 Dec 2025

1. HIVEP3 is associated with Alzheimer's disease in humans (OR = 0.24, p = 6.46 x 10 ‐6).

   “Regional analysis revealed significant associations for eight correlated variants in the HIVEP3 gene on chromosome 1, comparing SA to AD (peak signal at rs12734651, OR = 0.24, p = 6.46 x 10 ‐6 ).”

   Humanscomparing SA to AD

   Common genetic variants in HIVEP3 are associated with cognitive SuperAging in the Amish

   AAIC 2025 abstract·24 Dec 2025

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