GOLPH3
- 2 independent labs in 2 countries
- Humans1
- Cells1
Interventions
2Hydrogen peroxide
downin human cells1
1 study
Hydrogen peroxide
downin human cells1
Hydrogen peroxide decreases GOLPH3 in human cells.
“Ultraviolet A (UVA) irradiation and hydrogen peroxide (H2O2) treatment significantly reduced GOLPH3 protein levels”
CellsH2O2 treatment
GOLPH3 regulates fibronectin production via TGF-β/SMAD signaling in dermal fibroblasts
Biochemical and biophysical research communicationsMay 13, 2026
Ultraviolet a
downin human cells1
1 study
Ultraviolet a
downin human cells1
Ultraviolet a decreases GOLPH3 in human cells.
“Ultraviolet A (UVA) irradiation and hydrogen peroxide (H2O2) treatment significantly reduced GOLPH3 protein levels”
CellsUVA irradiation
GOLPH3 regulates fibronectin production via TGF-β/SMAD signaling in dermal fibroblasts
Biochemical and biophysical research communicationsMay 13, 2026
Effects
1Memory score
downin humans1
1 study
Memory score
downin humans1
GOLPH3 decreases memory score in humans (β=-0.047, p = 2.6x10-8).
“a region on chromosome 5 (rs36110370, MAF=0.182), near the GOLPH3 gene, showed consistent association with lower memory score”
Humansadjusted for sex, age, sequencing center, study, education, and PCsn = 9,698
Addressing Heterogeneity in Genetic Studies of Cognitive Function: Insights from the ADSP‐PHC
AAIC 2025 abstractDec 23, 2025