GOLPH3

Gene

2 papers3 findings

HGNCNCBI GeneTaxon

  • 2 independent labs in 2 countries
  • Humans1
  • Cells1

Interventions

2

Hydrogen peroxide

downin human cells1

1 study
  1. Hydrogen peroxide decreases GOLPH3 in human cells.

    “Ultraviolet A (UVA) irradiation and hydrogen peroxide (H2O2) treatment significantly reduced GOLPH3 protein levels”

    CellsH2O2 treatment

    GOLPH3 regulates fibronectin production via TGF-β/SMAD signaling in dermal fibroblasts

    Biochemical and biophysical research communicationsMay 13, 2026

More on Hydrogen peroxide

Ultraviolet a

downin human cells1

1 study
  1. Ultraviolet a decreases GOLPH3 in human cells.

    “Ultraviolet A (UVA) irradiation and hydrogen peroxide (H2O2) treatment significantly reduced GOLPH3 protein levels”

    CellsUVA irradiation

    GOLPH3 regulates fibronectin production via TGF-β/SMAD signaling in dermal fibroblasts

    Biochemical and biophysical research communicationsMay 13, 2026

More on Ultraviolet a

Effects

1

Memory score

downin humans1

1 study
  1. GOLPH3 decreases memory score in humans (β=-0.047, p = 2.6x10-8).

    “a region on chromosome 5 (rs36110370, MAF=0.182), near the GOLPH3 gene, showed consistent association with lower memory score”

    Humansadjusted for sex, age, sequencing center, study, education, and PCsn = 9,698

    Addressing Heterogeneity in Genetic Studies of Cognitive Function: Insights from the ADSP‐PHC

    AAIC 2025 abstractDec 23, 2025

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