GLRX3

1. GLRX3 increases neuropathic pain in mice.

   “Satellite glial cell-targeted knockdown of GLRX3 restored HMGB1 glutathionylation and reversed the pain phenotype specifically in aged mice.”

   Animalschronic phase of OIPNdorsal root ganglion satellite glial cells

   Satellite glial GLRX3 drives ageing-biased neuropathic pain via HMGB1

   Brain : a journal of neurology·20 Apr 2026

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1. GLRX3 extends lifespan in yeast cells.

   “Moreover, the heterologous expression of Glrx3 efficiently complements the novel participation in chronological life span that has been characterized for both Grx3 and Grx4.”

   Cells

   Interactions of GMP with Human Glrx3 and with Saccharomyces cerevisiae Grx3 and Grx4 Converge in the Regulation of the Gcn2 Pathway

   Applied and environmental microbiology·2 Jul 2020

1. GLRX3 inhibits integrated stress response in yeast cells.

   “Both proteins carry out collaborative functions regarding the downregulation of the Saccharomyces cerevisiae Gcn2 pathway under conditions of nutritional stress.”

   Cellsunder nutritional stress

   Interactions of GMP with Human Glrx3 and with Saccharomyces cerevisiae Grx3 and Grx4 Converge in the Regulation of the Gcn2 Pathway

   Applied and environmental microbiology·2 Jul 2020

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