Gcn2

1 paper1 finding

NCBI Gene Taxon

1 lab in 1 country

Funders: Royal Society and 1 more

Model organisms1

Effects

1

Lifespan

downin flies1

1 study

Gcn2 shortens lifespan in flies.
“overexpression of dGCN2 and dATF4 significantly reduces lifespan”
Model organismsshown by Gcn2 overexpression
Suppression rather than activation of the integrated stress response (GCN2-ATF4) pathway extends lifespan in the fly
Proceedings of the National Academy of Sciences of the United States of America28 Apr 2026

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PNAS28 Apr

Suppression rather than activation of the integrated stress response (GCN2-ATF4) pathway extends lifespan in the fly

Experiments in fliesIntegrated stress response