TRPV2
1 paper4 findings
- 1 lab in 1 country
- Animals1
Effects
3Oxidative stress and ROS signalling
upin human cells1upin mouse cells1
1 study
Oxidative stress and ROS signalling
upin human cells1upin mouse cells1
TRPV2 increases oxidative stress and ROS signalling in human cells.
“whereas TRPV2 knockdown in SH-SY5Y cells (a human neuroblastoma cell line) markedly mitigated the oxidative injury as reflected by reduced 4-HNE”
Cellsshown by knockdownSH-SY5Y cells
Molecular brain6 Mar 2026
TRPV2 increases oxidative stress and ROS signalling in mouse cells.
“In primary SGN cultures, TRPV2 overexpression aggravated oxidative stress”
CellsTRPV2 overexpressionspiral ganglion neurons
Molecular brain6 Mar 2026
Apoptosis
upin mice1
1 study
Apoptosis
upin mice1
TRPV2 increases apoptosis in mice.
“TRPV2 activation exacerbated oxidative damage (assessed by 4-HNE staining) and increased apoptotic cell death (detected via TUNEL) in the SGN population”
Animalspharmacological activation of TRPV2spiral ganglion neurons
Molecular brain6 Mar 2026
High-frequency hearing damage
upin mice1
1 study
High-frequency hearing damage
upin mice1
TRPV2 increases high-frequency hearing damage in mice.
“Pharmacological activation of TRPV2 in 6-month-old mice (a pre-senescent stage with preserved baseline hearing) accelerated the onset of high-frequency hearing damage”
Animalspharmacological activation of TRPV2
Molecular brain6 Mar 2026