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GIMAP5

Gene

1 paper3 findings

HGNCNCBI GeneTaxon

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Includes the processes named after it and trials of drugs aimed at it.

  • 1 lab in 1 country
  • Funders: Biotechnology and Biological Sciences Research Council and others
  • Cells1

Effects

3

Long-chain ceramides

downin human cells1

1 study

  1. GIMAP5 decreases long-chain ceramides in human cells.

    “GIMAP5 restricts the pathological accumulation of long-chain ceramides (CERs), thereby regulating longevity”

    Cells

    GIMAP5 deficiency reveals a mammalian ceramide-driven longevity assurance pathway

    Nature immunology3 Jan 2024

More on Long-chain ceramides

Mortality

downin humans1

1 study

  1. GIMAP5 protects against mortality in humans.

    “causes cell senescence, liver and immune dysfunction, and early mortality that results from deficiency of GIMAP5”

    Humansdeficiency

    GIMAP5 deficiency reveals a mammalian ceramide-driven longevity assurance pathway

    Nature immunology3 Jan 2024

Cellular senescence

downin humans1

1 study

  1. GIMAP5 prevents cellular senescence in humans.

    “Here, we report a new human genetic disease that causes cell senescence, liver and immune dysfunction, and early mortality that results from deficiency of GIMAP5”

    Humansdeficiency

    GIMAP5 deficiency reveals a mammalian ceramide-driven longevity assurance pathway

    Nature immunology3 Jan 2024

More on Cellular senescence

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