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GFRAL

Gene

1 paper1 finding

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

Includes the processes named after it and trials of drugs aimed at it.

  • 1 lab in 1 country
  • 1 of 1 finding with company ties
  • Animals1

Effects

1

Energy expenditure

is required forin mice1

1 study

  1. GFRAL is required for energy expenditure in mice.

    “This effect of GDF15 to maintain energy expenditure during calorie restriction requires a GFRAL-β-adrenergic-dependent signalling axis”

    Animalsshown by requirement for GDF15 effect on energy expenditure during calorie restrictionskeletal muscle

    GDF15 promotes weight loss by enhancing energy expenditure in muscle

    NatureJun 28, 2023

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