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Growth differentiation factor 15

Intervention

1 paper4 findings

MeSH D055436

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab in 1 country
  • Cells1

Outcomes

4

Oxidative stress and ROS signalling

no changein human cells1

1 study

  1. Growth differentiation factor 15 has no effect on oxidative stress and ROS signalling in human cells.

    “without triggering any oxidative stress”

    Cellsin non-senescent AB-ECFCs

    GDF15 secreted by senescent endothelial cells improves vascular progenitor cell functions

    PloS one10 May 2019

More on Oxidative stress and ROS signalling

Nitric oxide

upin human cells1

1 study

  1. Growth differentiation factor 15 increases nitric oxide in human cells.

    “GDF15 enhanced proliferation, migration, NO production”

    Cellsin non-senescent AB-ECFCs

    GDF15 secreted by senescent endothelial cells improves vascular progenitor cell functions

    PloS one10 May 2019

More on Nitric oxide

Endothelial cell migration

upin human cells1

1 study

  1. Growth differentiation factor 15 increases endothelial cell migration in human cells.

    “GDF15 enhanced proliferation, migration, NO production”

    Cellsin non-senescent AB-ECFCs

    GDF15 secreted by senescent endothelial cells improves vascular progenitor cell functions

    PloS one10 May 2019

Endothelial cell proliferation

upin human cells1

1 study

  1. Growth differentiation factor 15 increases endothelial cell proliferation in human cells.

    “GDF15 enhanced proliferation, migration, NO production”

    Cellsin non-senescent AB-ECFCs

    GDF15 secreted by senescent endothelial cells improves vascular progenitor cell functions

    PloS one10 May 2019

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