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G6PDX

Gene

7 papers2 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Includes the processes named after it and trials of drugs aimed at it.

  • 1 lab in 1 country
  • Funders: Canadian Institutes of Health Research and 3 more
  • Animals4
  • Cells1

Effects

2

Lifespan

upin mice1

1 study

  1. G6PDX extends lifespan in mice.

    “G6PD overexpression in Drosophila Melanogaster and mice protects against metabolic stress, oxidative damage, and age-associated functional decline, and results in an extended median lifespan.”

    ReviewG6PD overexpression

    Glucose 6-P Dehydrogenase-An Antioxidant Enzyme with Regulatory Functions in Skeletal Muscle during Exercise

    Cells28 Sep 2022

DNA damage

downin mice1

1 study

  1. G6PDX protects against DNA damage in mice.

    “DNA comet formation was increased and Purkinje cell counts were decreased in a G6pd gene dose-dependent fashion.”

    Animalsin G6pd-deficient micebrain

    DNA damage and synaptic and behavioural disorders in glucose-6-phosphate dehydrogenase-deficient mice

    Redox biology18 Sep 2019

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