What does the research say about FZO1?

FZO1

There are 4 papers on FZO1 in aging research: none in people yet, 4 in cells. The newest story, Nov 3, 2026: “Loss of Atp12 protein shortens lifespan in fission yeast”.

Gene

4 papers study it3 findings

Taxon

1 new paper in 30 daysSee all 4 papers on FZO1

At a glance

The findings reach worms or flies, none yet in people. 2 independent labs in 2 countries.

None of its findings points the other way.

2 independent labs in 2 countries

Funders: National Institute for Health Research and 3 more

Cells4

Effects

Mitochondrial fragmentation

downin fission yeast cells1

1 study

FZO1 decreases mitochondrial fragmentation in fission yeast cells (fzo1 overexpression in atp12-deleted cells).
“Fzo1 insufficiency largely accounts for the mitochondrial fragmentation and functional decline observed in Δ atp12 cells, as Fzo1 overexpression effectively rescues these defects.”
Cellsfzo1 overexpression in atp12-deleted cells
Loss of Atp12 protein shortens lifespan in fission yeast
Microbiology spectrumNov 3, 2026

Mitophagy

upin yeast cells1

1 study

FZO1 activates mitophagy in yeast cells (shown by deletion).
“we have also discovered that deletion of FZO1 reduces mitophagy”
Cellsshown by deletion
Dual roles of mitochondrial fusion gene FZO1 in yeast age asymmetry and in longevity mediated by a novel ATG32-dependent retrograde response
BiogerontologyOct 8, 2018

Latest

1 paper in 12 months

Microbiology SpectrumNov 3

Loss of Atp12 protein shortens lifespan in fission yeast

Experiments in fission yeast showed that the protein stabilizes machinery that joins mitochondria, the cells’ energy-producing structures, together.Experiments in fission yeast showed that the protein stabilizes machinery that joins mitochondria, the cells’ energy-producing structures, together.

Cell studyMechanisms