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FGF13

There are 2 papers on FGF13 in aging research: none in people yet, 2 in animals. The newest story, Oct 30, 2026: “Increasing a brain protein delayed signs of aging in mice”.

Gene

2 papers study it4 findings

HGNCNCBI GeneTaxon

1 new paper in 30 daysSee all 2

None of its findings points the other way.

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Includes the processes named after it and trials of drugs aimed at it.

  • 2 independent labs in 1 country
  • Funders: Beijing Friendship Hospital and 2 more
  • Animals2

Effects

4

Autophagy

upin mice1

1 study

  1. FGF13 activates autophagy in mice.

    “Mechanistically, FGF13 targets and binds to Phafin2, promoting autophagy in astrocytes.”

    Animalsastrocyte

    Increasing a brain protein delayed signs of aging in mice

    Aging cell

More on Autophagy

Cognitive function

upin mice1

1 study

  1. FGF13 improves cognitive function in mice (FGF13 overexpression during aging).

    “Conversely, overexpression of FGF13 effectively delays the aging process and ameliorates aging‐induced cognitive impairment.”

    AnimalsFGF13 overexpression during agingbrain

    Increasing a brain protein delayed signs of aging in mice

    Aging cell

Spiral ganglion neuron

downin mice1

1 study

  1. FGF13 protects against spiral ganglion neuron in mice (specific upregulation in SGNs).

    “improved wave I amplitude, and alleviated loss of SGNs as well as ribbon synapses”

    Animalsspecific upregulation in SGNsspiral ganglion neurons

    FGF13 prevents age-related hearing loss by protecting spiral ganglion neurons and ribbon synapses from injury

    Cell death discovery

Hearing threshold

upin mice1

1 study

  1. FGF13 improves hearing threshold in mice (specific upregulation in SGNs).

    “specific upregulation of FGF13 in SGNs significantly reduced hearing threshold”

    Animalsspecific upregulation in SGNsspiral ganglion neurons

    FGF13 prevents age-related hearing loss by protecting spiral ganglion neurons and ribbon synapses from injury

    Cell death discovery

More on Hearing threshold

Latest

Dec 2025: 0Jan 2026: 0Feb 2026: 0Mar 2026: 0Apr 2026: 0May 2026: 0Jun 2026: 0Jul 2026: 0Aug 2026: 0Sep 2026: 0Oct 2026: 1Nov 2026: 01 paper in 12 months
Aging Cell

Increasing a brain protein delayed signs of aging in mice

Removing the protein from brain support cells accelerated aging-related changes and impaired nervous system function in mouse experiments.Removing the protein from brain support cells accelerated aging-related changes and impaired nervous system function in mouse experiments.

Mouse studyMechanisms
Paper

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