FBXL19
- 1 lab in 1 country
- Funders: Foundation for the National Institutes of Health and 2 more
- Humans1
- Animals1
Effects
4Viral titer
downin mice1
1 study
Viral titer
downin mice1
FBXL19 decreases viral titer in mice.
“FBXL19 overexpression in endothelial cells (ECs) reduced viral titers and IAV matrix protein 1 (M1) levels while increasing antiviral gene expression”
Animalsin IAV-infected miceheart
American journal of physiology. Heart and circulatory physiologyAug 16, 2024
Cellular senescence
downin mice1
1 study
Cellular senescence
downin mice1
FBXL19 decreases cellular senescence in mice.
“IAV infection triggered cellular senescence programs in the heart as indicated by the upregulation of p16 and p21 mRNA levels and the downregulation of lamin-B1 levels, which were partially reversed by FBXL19 overexpression in ECs.”
Animalsin IAV-infected miceheart
American journal of physiology. Heart and circulatory physiologyAug 16, 2024
Inflammation
downin mice1
1 study
Inflammation
downin mice1
FBXL19 decreases inflammation in mice.
“EC-specific overexpression of FBXL19 attenuated the IAV infection-reduced interferon regulatory factor 3 (IRF3) level without altering its mRNA level and suppressed cardiac inflammation.”
Animalsin IAV-infected miceheart
American journal of physiology. Heart and circulatory physiologyAug 16, 2024
Cardiac damage
downin mice1
1 study
Cardiac damage
downin mice1
FBXL19 protects against cardiac damage in mice.
“Our findings indicate that EC-specific overexpression of FBXL19 protects against IAV-induced cardiac damage by enhancing interferon-mediated antiviral signaling, reducing cardiac inflammation, and suppressing cellular senescence programs.”
Animalsin IAV-infected miceheart
American journal of physiology. Heart and circulatory physiologyAug 16, 2024
Latest
1 in 12 monthsClinical Epigenetics
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Cohort study in peoplePhenoAge
American Journal of Physiology Heart and Circulatory Physiology
FBXL19 in endothelial cells protects the heart from influenza A infection by enhancing antiviral immunity and reducing cellular senescence programs
Experiments in miceCellular senescence