CRHR1

1. CRHR1 decreases plasma corticosterone in mice.

   “CRF1 deficiency is also associated with decreased plasma corticosterone levels in both male and female mice.”

   Animals

   Genetic inactivation of the CRF₁ receptor eliminates age-linked elevation of hippocampal 11β-hydroxysteroid dehydrogenase type 1 activity in female mice

   Journal of neuroendocrinology·1 Jan 2026

More on Plasma corticosterone

1. CRHR1 decreases corticosterone in mice.

   “CRF1 deficiency leads to reduced hippocampal levels of both corticosterone and dehydrocorticosterone in males and females at both ages.”

   Animalshippocampus

   Genetic inactivation of the CRF₁ receptor eliminates age-linked elevation of hippocampal 11β-hydroxysteroid dehydrogenase type 1 activity in female mice

   Journal of neuroendocrinology·1 Jan 2026

More on Corticosterone

1. CRHR1 increases 11β-HSD1 activity in mice.

   “In females, this increase is dependent on the presence of functional CRF1 receptors.”

   Animalsaginghippocampusfemales

   Genetic inactivation of the CRF₁ receptor eliminates age-linked elevation of hippocampal 11β-hydroxysteroid dehydrogenase type 1 activity in female mice

   Journal of neuroendocrinology·1 Jan 2026

More on 11β-HSD1 activity