AFF3

AFF3 increases CD8 T cell accumulation following viral infection in mice.

“they have reduced accumulation in response to viral infection, and this is correlated with a poor capacity to engage glycolysis.”

Animalsshown by AFF3 deficiencyCD8 T cell

AFF3 maintains metabolic quiescence in naive CD8 T cells and prevents premature immune aging

JCI insight·23 Jun 2026

AFF3 increases metabolic quiescence in mice.

“While naive AFF3-deficient CD8 T cells are more metabolically active prior to infection”

Animalsshown by AFF3 deficiency before infectionnaive CD8 T cell

AFF3 maintains metabolic quiescence in naive CD8 T cells and prevents premature immune aging

JCI insight·23 Jun 2026