DNAm PhenoAge acceleration

1. Lead increases DNAm PhenoAge acceleration in humans (+1.29 years (95% CI 0.47 to 2.11) per IQR).

   “an interquartile range (IQR, 0.0011 μg/m3) increase in lead was associated with a 1.29-year [95% confidence interval (CI): 0.47, 2.11] increase in DNAmPhenoAccel.”

   Humanswhole bloodone-yearmalesn = 683

   Associations of annual ambient PM2.5 components with DNAm PhenoAge acceleration in elderly men: The Normative Aging Study

   Environmental pollution (Barking, Essex : 1987)·29 Nov 2019

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1. DNAm PhenoAge acceleration is associated with incident atrial fibrillation in humans (Adjusted HR 1.15 (95% CI 1.05–1.25) per 5-year increase).

   “and 15% (adjusted HR, 1.15 [95% CI, 1.05-1.25]; P<0.01) higher hazards of incident AF, respectively.”

   HumansMultivariable adjustment for chronological age and AF risk factors5-year increase in epigenetic age accelerationMean follow-up of 12.9 yearsFemale, 60.1%sn = 5,600

   Epigenetic Age and the Risk of Incident Atrial Fibrillation

   Circulation·30 Sep 2021

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1. Calcium is associated with DNAm PhenoAge acceleration in humans.

   “Using LME model, only lead and calcium were significantly associated with DNAmPhenoAccel.”

   Humanswhole bloodone-yearmalesn = 683

   Associations of annual ambient PM2.5 components with DNAm PhenoAge acceleration in elderly men: The Normative Aging Study

   Environmental pollution (Barking, Essex : 1987)·29 Nov 2019

More on Calcium