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DWORF

Gene

2 papers6 findings

HGNCNCBI GeneTaxon

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Against: findings that point the other way from most findings on the same outcome.

Includes the processes named after it and trials of drugs aimed at it.

  • 1 lab in 1 country
  • 1 finding against
  • Funders: Universitair Medisch Centrum Groningen and others
  • Animals2

Effects

5

Cardiac fibrosis

no changein mice1downin mice1

2 studies

  1. DWORF has no effect on cardiac fibrosis in mice.

    “did not exacerbate cardiac fibrosis caused by the R14Δ/+ mutation.”

    Animalsin mice harboring the pathogenic R14del alleleheart

    Deletion of DWORF does not affect cardiac function in aging and in PLN-R14del cardiomyopathy

    American journal of physiology. Heart and circulatory physiology9 Feb 2024

  2. DWORF decreases cardiac fibrosis in mice.

    “Restoration of DWORF expression in R14Δ/Δ mice delayed cardiac fibrosis and heart failure”

    Animalsin homozygous PLN-R14del miceheart

    DWORF Extends Life Span in a PLN-R14del Cardiomyopathy Mouse Model by Reducing Abnormal Sarcoplasmic Reticulum Clusters

    Circulation research13 Nov 2023

Left ventricular ejection fraction

no changein mice1

1 study

  1. DWORF has no effect on left ventricular ejection fraction in mice.

    “DWORF-/- mice maintained a normal left ventricular ejection fraction (LVEF) during aging and no difference with WT control mice could be observed up to 20 mo of age.”

    Animalsagingheart

    Deletion of DWORF does not affect cardiac function in aging and in PLN-R14del cardiomyopathy

    American journal of physiology. Heart and circulatory physiology9 Feb 2024

Perinuclear PLN clusters

downin mice1

1 study

  1. DWORF decreases perinuclear PLN clusters in mice.

    “DWORF overexpression delayed the appearance and formation of large pathogenic perinuclear PLN clusters.”

    Animalsin homozygous PLN-R14del miceheart

    DWORF Extends Life Span in a PLN-R14del Cardiomyopathy Mouse Model by Reducing Abnormal Sarcoplasmic Reticulum Clusters

    Circulation research13 Nov 2023

More on Perinuclear PLN clusters

Heart failure

downin mice1

1 study

  1. DWORF decreases heart failure in mice.

    “delayed cardiac fibrosis and heart failure”

    Animalsin homozygous PLN-R14del miceheart

    DWORF Extends Life Span in a PLN-R14del Cardiomyopathy Mouse Model by Reducing Abnormal Sarcoplasmic Reticulum Clusters

    Circulation research13 Nov 2023

More on Heart failure

Lifespan

upin mice1

1 study

  1. DWORF extends lifespan in mice (>2-fold (from 8 to 18 weeks)).

    “increased life span >2-fold (from 8 to 18 weeks).”

    Animalsin homozygous PLN-R14del micefrom 8 to 18 weeks

    DWORF Extends Life Span in a PLN-R14del Cardiomyopathy Mouse Model by Reducing Abnormal Sarcoplasmic Reticulum Clusters

    Circulation research13 Nov 2023

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