Perinuclear PLN clusters

1. DWORF decreases perinuclear PLN clusters in mice.

   “DWORF overexpression delayed the appearance and formation of large pathogenic perinuclear PLN clusters.”

   Animalsin homozygous PLN-R14del miceheart

   DWORF Extends Life Span in a PLN-R14del Cardiomyopathy Mouse Model by Reducing Abnormal Sarcoplasmic Reticulum Clusters

   Circulation research·Nov 13, 2023

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