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DOT1

There are 3 papers on DOT1 in aging research: none in people yet, 3 in cells. The newest story, Nov 9, 2026: “Chemical tags mark ribosomes for recycling in yeast”.

Gene

3 papers study it2 findings

Taxon

1 new paper in 30 daysSee all 3 papers on DOT1

At a glance

The findings reach worms or flies, none yet in people. 2 independent labs in 1 country.

None of its findings points the other way.

Worms or flies: a single group. Cells, mice and humans: nothing yet.

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Includes the processes named after it and trials of drugs aimed at it.

  • 2 independent labs in 1 country
  • Funders: American Federation for Aging Research and 7 more
  • Cells3

Effects

2

ribophagy

upin yeast cells1

1 study

  1. DOT1 activates ribophagy in yeast cells under nutrient deprivation.

    “Dot1 methylates Rpl12 at K41 and K48 in Saccharomyces cerevisiae, enhancing its interaction with Atg11 and initiating ribophagy”

    Cellsunder nutrient deprivation

    Chemical tags mark ribosomes for recycling in yeast

    Molecular cell

Cellular senescence delay

is required forin yeast cells1

1 study

  1. DOT1 is required for cellular senescence delay in yeast cells.

    “the anti-TERRA delay is independent of the C-terminal methyltransferase domain of Dot1 and instead requires only its N-terminus”

    Cellsanti-TERRA-mediated delay; requires the Dot1 N-terminus, not its C-terminal methyltransferase domain

    TERRA and the histone methyltransferase Dot1 cooperate to regulate senescence in budding yeast

    PloS one

Latest

Dec 2025: 0Jan 2026: 0Feb 2026: 0Mar 2026: 0Apr 2026: 0May 2026: 0Jun 2026: 0Jul 2026: 0Aug 2026: 0Sep 2026: 0Oct 2026: 0Nov 2026: 11 paper in 12 months
Molecular Cell

Chemical tags mark ribosomes for recycling in yeast

Experiments in nutrient-deprived yeast identified how an enzyme labels the cell’s protein-making machinery for breakdown through a recycling process.Experiments in nutrient-deprived yeast identified how an enzyme labels the cell’s protein-making machinery for breakdown through a recycling process.

Cell studyMechanisms
Paper

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