AgingResearch.NewsJoin free

NPL3

There are 2 papers on NPL3 in aging research: none in people yet, 2 in cells.

Gene

2 papers study it6 findings

Taxon

See all 2 papers on NPL3

At a glance

The findings reach worms or flies, none yet in people. 2 independent labs in 2 countries.

None of its findings points the other way.

Cells and worms or flies: a single group. Mice and humans: nothing yet.

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Includes the processes named after it and trials of drugs aimed at it.

  • 2 independent labs in 2 countries
  • Funder: Deutsche Forschungsgemeinschaft
  • Cells2

Effects

4

Cellular senescence

downin cells1downin yeast cells1

2 studies

  1. NPL3 inhibits cellular senescence in yeast cells (tlc1Δ cells (shown by deletion)).

    “Deletion of Npl3, an RNA-processing protein with telomere maintenance functions, accelerates senescence in tlc1Δ cells”

    Cellstlc1Δ cells (shown by deletion)

    Yeast Npl3 regulates replicative senescence outside of TERRA R-loop resolution and co-transcriptional processing

    Nucleosides, nucleotides & nucleic acids

  2. NPL3 prevents cellular senescence in cells (at short telomeres).

    “prevents premature replicative senescence onset”

    Cellsat short telomeres

    Npl3 stabilizes R-loops at telomeres to prevent accelerated replicative senescence

    EMBO reports

More on Cellular senescence

TERRA

downin yeast cells1

1 study

  1. NPL3 decreases TERRA in yeast cells (tlc1Δ cells (shown by deletion)).

    “accelerates senescence in tlc1Δ cells and significantly increases TERRA levels”

    Cellstlc1Δ cells (shown by deletion)

    Yeast Npl3 regulates replicative senescence outside of TERRA R-loop resolution and co-transcriptional processing

    Nucleosides, nucleotides & nucleic acids

More on TERRA

homology-directed repair

upin cells1

1 study

  1. NPL3 activates homology-directed repair in cells (at short telomeres).

    “which in turn promotes HDR and prevents premature replicative senescence onset”

    Cellsat short telomeres

    Npl3 stabilizes R-loops at telomeres to prevent accelerated replicative senescence

    EMBO reports

R-loop stability at short telomeres

upin cells1

1 study

  1. NPL3 increases R-loop stability at short telomeres in cells.

    “Npl3 binds to TERRA and stabilizes R-loops at short telomeres”

    Cells

    Npl3 stabilizes R-loops at telomeres to prevent accelerated replicative senescence

    EMBO reports

Associations

1

Telomeres

upin cells1

1 study

  1. NPL3 is associated with telomeres in cells (R-loop-dependent).

    “Npl3 associates with telomeres in an R-loop-dependent manner”

    CellsR-loop-dependent

    Npl3 stabilizes R-loops at telomeres to prevent accelerated replicative senescence

    EMBO reports

Latest

Related