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DOCK11

There are 3 papers on DOCK11 in aging research: none in people yet, 3 in animals.

Gene

3 papers study it2 findings

HGNCNCBI GeneTaxon

See all 3

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Includes the processes named after it and trials of drugs aimed at it.

  • 1 lab in 1 country
  • Animals3

Effects

2

Cellular senescence

downin mice1

1 study

  1. DOCK11 decreases cellular senescence in Dcaf8-/- HSCs.

    “Knocking out Dock11 mitigates the senescence, DNA damage, and self-renewal defects of Dcaf8-/- HSCs.”

    Animalsin Dcaf8-/- HSCs

    Loss of DCAF8 impairs hematopoietic stem cell function with cellular senescence via the DOCK11-CDC42 axis

    Blood

More on Cellular senescence

Expression in B-1a cells

downin mice1

1 study

  1. DOCK11 decreases expression in B-1a cells in B-1a cells.

    “Although DOCK11 was expressed by B-1a cells, the expression levels declined with age.”

    Reviewin B-1a cells

    Immunosenescence: The Forefront of Infection and Trophic Control

    Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan

More on Expression in B-1a cells

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