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DCAF8

There are 3 papers on DCAF8 in aging research: none in people yet, 2 in animals, 1 in cells.

Gene

3 papers study it2 findings

HGNCNCBI GeneTaxon

See all 3

None of its findings points the other way.

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Includes the processes named after it and trials of drugs aimed at it.

  • 2 independent labs in 2 countries
  • Funders: American Cancer Society and others
  • Animals2
  • Cells1

Effects

2

Cellular senescence

downin mice1

1 study

  1. DCAF8 prevents cellular senescence in mice (shown by knockout in mice).

    “associates with cellular senescence and elevated DNA damage.”

    Animalsshown by knockout in mice

    Loss of DCAF8 impairs hematopoietic stem cell function with cellular senescence via the DOCK11-CDC42 axis

    Blood

More on Cellular senescence

DNMT3A protein degradation

mediatesin human cells1

1 study

  1. DCAF8 mediates DNMT3A protein degradation in human cells (shown by CRISPR screen).

    “uncovered regulated destruction of DNMT3A mediated by the DCAF8 E3 ubiquitin ligase adaptor”

    Cellsshown by CRISPR screen

    Systematic Profiling of DNMT3A Variants Reveals Protein Instability Mediated by the DCAF8 E3 Ubiquitin Ligase Adaptor

    Cancer discovery

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