What does the research say about DOCK10?

DOCK10

There are 3 papers on DOCK10 in aging research: none in people yet, 3 in animals. The newest story, Nov 1, 2026: “Chemical exposure induced an aging state in animal nerve cells”.

Gene

3 papers study it3 findings

HGNC NCBI Gene Taxon

1 new paper in 30 daysSee all 3

None of its findings points the other way.

1 lab in 1 country

Funders: European Commission and 2 more

Animals3

Effects

Coat loss during aging

upin mice1

1 study

DOCK10 increases coat loss during aging in mice (shown by knockout).
“Dock10-KO mice showed slower loss of their coat during aging”
Animalsshown by knockout
The role of DOCK10 in the regulation of the transcriptome and aging
HeliyonMar 23, 2019

Lifespan

downin mice1

1 study

DOCK10 shortens lifespan in mice (shown by knockout).
“we set out to analyse the survival of the mouse colony, which led to the finding that Dock10-KO mice lived longer than WT mice”
Animalsshown by knockout
The role of DOCK10 in the regulation of the transcriptome and aging
HeliyonMar 23, 2019

Associations

Cellular senescence

upin mice1

1 study

DOCK10 is associated with cellular senescence in mice (wild-type versus Dock10-knockout spleen B cells).
“Interestingly, a senescence gene set was found significantly associated to WT SBC”
Animalswild-type versus Dock10-knockout spleen B cellsspleen B cells
The role of DOCK10 in the regulation of the transcriptome and aging
HeliyonMar 23, 2019

Latest

1 paper in 12 months

Journal of Hazardous MaterialsNov 1

Chemical exposure induced an aging state in animal nerve cells

Deleting a gene reduced this response in animal experiments examining how an emerging environmental chemical affected nerve cells.Deleting a gene reduced this response in animal experiments examining how an emerging environmental chemical affected nerve cells.

Animal studyMechanisms