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DGAT2

Gene

2 papers2 findings

Taxon

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Includes the processes named after it and trials of drugs aimed at it.

  • 1 lab in 1 country
  • Funders: National Institute on Aging and 1 more
  • Animals1
  • Model organisms1

Interventions

1

Time-restricted feeding

upin flies1

1 study

  1. Time-restricted feeding induces DGAT2 in flies.

    “In particular, TRF induces diurnal expression of diacylglycerol O-acyltransferase 2 (Dgat2), peaking during the feeding period.”

    Model organismsduring feeding period in Drosophila with constant light

    Diurnal expression of Dgat2 induced by time-restricted feeding maintains cardiac health in the Drosophila model of circadian disruption

    Aging cellApr 14, 2024

More on Time-restricted feeding

Effects

1

Cardiac performance

upin flies1

1 study

  1. DGAT2 improves cardiac performance in flies.

    “Strikingly, heart-specific overexpression of human Dgat2 at ZT 0-10 significantly improves cardiac performance in flies exposed to constant light.”

    Model organismsin flies exposed to constant lightheart

    Diurnal expression of Dgat2 induced by time-restricted feeding maintains cardiac health in the Drosophila model of circadian disruption

    Aging cellApr 14, 2024

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