DEAF1

2 papers8 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

A gene’s or a process’s line counts the gene with the processes named after it, as NLRP3 with the NLRP3 inflammasome, and the trials of drugs aimed at it.

1 lab in 1 country

Funders: National Medical Research Council and 4 more

Animals2

Interventions

Exercise

downin animals1downin mice1

2 studies

Exercise decreases DEAF1.
“Exercise reverses DEAF1 induction, restoring autophagy and muscle function.”
Animalsskeletal muscle
DEAF1 - a transcriptional brake on muscle autophagy
Autophagy28 Dec 2025
Exercise decreases DEAF1 in mice.
“exercise suppresses Deaf1 expression via FOXO activation, restoring mTORC1 balance and alleviating muscle aging.”
Animalsskeletal muscle
Exercise suppresses DEAF1 to normalize mTORC1 activity and reverse muscle aging
Proceedings of the National Academy of Sciences of the United States of America24 Nov 2025

Effects

Cell death

upin animals1

1 study

DEAF1 increases cell death.
“becomes aberrantly elevated with age, promoting protein aggregate formation and cell death.”
Animalswith agemuscle stem cells
DEAF1 - a transcriptional brake on muscle autophagy
Autophagy28 Dec 2025

Protein aggregates

upin animals1

1 study

DEAF1 increases protein aggregates.
“becomes aberrantly elevated with age, promoting protein aggregate formation and cell death.”
Animalswith agemuscle stem cells
DEAF1 - a transcriptional brake on muscle autophagy
Autophagy28 Dec 2025

Muscle function

downin animals1

1 study

DEAF1 impairs muscle function.
“In muscle fibers, DEAF1 is chronically induced during aging, suppressing autophagy and driving functional decline.”
Animalsduring agingmuscle fibers
DEAF1 - a transcriptional brake on muscle autophagy
Autophagy28 Dec 2025

Autophagy

downin animals1

1 study

DEAF1 inhibits autophagy.
“In muscle fibers, DEAF1 is chronically induced during aging, suppressing autophagy and driving functional decline.”
Animalsduring agingmuscle fibers
DEAF1 - a transcriptional brake on muscle autophagy
Autophagy28 Dec 2025