CrebB

3 papers3 findings

NCBI Gene Taxon

2 independent labs in 2 countries

Funders: National Natural Science Foundation of China and 5 more

Model organisms3

Effects

3

Lifespan

is required forin flies1

1 study

CrebB is required for lifespan in flies.
“CrebB links the ß-adrenergic pathway to longevity-promoting processes in the gut where its function is required for the beneficial effects of TA feeding in females.”
Model organismsbeneficial effects of TA feedinggutfemales
ß-adrenergic-like signalling engages CrebB in Drosophila gut to promote female longevity
Nature communications2 Apr 2026

PGRP-SC2

downin flies1

1 study

CrebB inhibits PGRP-SC2 in flies.
“CREB), activated by JNK signaling in aging guts, transcriptionally suppresses peptidoglycan recognition protein SC2(PGRP-SC2)”
Model organismsgut
CREB suppresses PGRP-SC2 to drive age-related immune senescence and gut dysbiosis in Drosophila
Cell death discovery24 Feb 2026

More on PGRP-SC2

Firmicutes/Bacteroidetes ratio

downin flies1

1 study

CrebB decreases Firmicutes/Bacteroidetes ratio in flies.
“Elevated CREB activity decreased the Firmicutes/Bacteroidetes (F/B) ratio-a hallmark of age-associated dysbiosis in animals.”
Model organismsgut
CREB suppresses PGRP-SC2 to drive age-related immune senescence and gut dysbiosis in Drosophila
Cell death discovery24 Feb 2026

More on Firmicutes/Bacteroidetes ratio

Latest

2 in 12 months

Nature Communications3 Apr

ß-adrenergic-like signalling engages CrebB in Drosophila gut to promote female longevity

Experiments in fliesGut and microbiome

Cell Death Discovery25 Feb

CREB suppresses PGRP-SC2 to drive age-related immune senescence and gut dysbiosis in Drosophila

Experiments in fliesMicrobiome composition

The Journal of Biological Chemistry7 May

Overexpression of neprilysin reduces alzheimer amyloid-beta42 (Abeta42)-induced neuron loss and intraneuronal Abeta42 deposits but causes a reduction in cAMP-responsive element-binding protein-mediated transcription, age-dependent axon pathology, and premature death in Drosophila

Experiments in fliesAlzheimer's disease