Intraneuronal Abeta42 deposits

1 paper1 finding

Model organisms1

Upstream

1

MME

downin flies1

1 study

MME decreases intraneuronal Abeta42 deposits in flies.
“NEP efficiently suppressed the formation of intraneuronal Abeta42 deposits and Abeta42-induced neuron loss.”
Model organismsin transgenic Drosophila expressing human NEP and Abeta42brain
Overexpression of neprilysin reduces alzheimer amyloid-beta42 (Abeta42)-induced neuron loss and intraneuronal Abeta42 deposits but causes a reduction in cAMP-responsive element-binding protein-mediated transcription, age-dependent axon pathology, and premature death in Drosophila
The Journal of biological chemistry7 May 2008

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The Journal of Biological Chemistry7 May

Overexpression of neprilysin reduces alzheimer amyloid-beta42 (Abeta42)-induced neuron loss and intraneuronal Abeta42 deposits but causes a reduction in cAMP-responsive element-binding protein-mediated transcription, age-dependent axon pathology, and premature death in Drosophila

Experiments in fliesAlzheimer's disease