PGRP-SC2

1. PGRP-SC2 decreases gut hyperplasia in flies.

   “Genetic enhancement of PGRP-SC2 rescues age-related gut hyperplasia, microbiota imbalance, and lifespan shortening induced by overactivation of CREB or its coactivator CRTC.”

   Model organismsinduced by overactivation of CREB or CRTCgut

   CREB suppresses PGRP-SC2 to drive age-related immune senescence and gut dysbiosis in Drosophila

   Cell death discovery·24 Feb 2026

1. CrebB inhibits PGRP-SC2 in flies.

   “CREB), activated by JNK signaling in aging guts, transcriptionally suppresses peptidoglycan recognition protein SC2(PGRP-SC2)”

   Model organismsgut

   CREB suppresses PGRP-SC2 to drive age-related immune senescence and gut dysbiosis in Drosophila

   Cell death discovery·24 Feb 2026

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